Asthmanefrin: DO NOT BUY


If you suffer from asthma and can’t afford a prescription inhaler you probably lament the loss of the Primatene Mist inhalers. So do I. If you go to your local pharmacy and see a product called Asthmanefrin, that is supposedly designed to replace Primatene, do yourself a favor, avoid it if at all possible.

Over the past couple of years I’ve purchased way too many of their starter kits that contains the inhalation solution and the EZ Breathe Atomizer.


The reason I keep buying the starter kit is because the atomizer always stops working after about two weeks. Asthmanefrin will tell you that you have to clean it properly after each use for the atomizer to function properly. In my experience that doesn’t help. All the atomizers I’ve ever had no matter how I maintained them died after two weeks and once they die that’s it. You can’t get them working again. So to get a new one you have to buy the starter kit again which goes for $50 a pop and above. Still cheaper than prescription inhalers but less cost-effective if you’re having to buy a new one every two weeks.

Last year I worked for a pharmaceutical company and had access to industry news sources. At that time it was being reported that Primatene was on its way back to the market with a newly designed inhaler. As of the time I’m writing this it has not yet been brought to market. We can only hope it hits our store shelves soon.


  1. karen jay

    What people don’t seem to realize, is Asthmanefrin is a form of epinephrine. Epinephrine is very different from Albuterol or Levalbuterol, the only 2 rescue inhalers available with a prescription. People like me get a paradoxical reaction to Albuterol and Levalbuterol along with many bad side-effects. Without the Asthmanefrin, my life will be ruined. I can’t breathe at night without it.
    My EZ-Breathe Atonomizer stopped working yesterday. I bought it in 2013 and didn’t know the FDA recalled it off the market. So I was up until 5 a.m. trying to breathe and found an old Atonomizer and took the old top part and rubberbanded it together with the newer bottom part with the motor that is still working and lucky me, it worked, for now. But then what? This is really going to ruin my life!
    I used cortisone for many years and can’t tolerate it either. My doctor says , sorry, there is nothing he can do. If I go to the emergency, because I am dying, they give me a shot of, guess what? Epinephrine, NOT Albuterol. My co-pay for an emergency is $400. I can’t afford that. So many people complained about the atonomizer and now it’s gone. Nothing to replace it. People that don’t have asthma need to put a pillow on their face and a gag in their mouth and keep it there, to get an idea of what it’s like to live with asthma. I only need it at night now. I have had NO bad side effects. Don’t I count? And others like me?

    1. Trench Reynolds

      I can empathize especially since my albuterol inhaler just ran out. Not only do I not have any refills but I don’t have the cash to get one anyway.

      However if you have the Asthmanefrin solution I’ve read that some people have had pretty good results using this nebulizer

      Although I can’t say with 100% certainty that it”s either safe or effective.

      1. karen jay

        Thank you So much! My husband ordered me one and it will be here Wednesday!! Yay!!

        1. Trench Reynolds

          Did they ask you for a prescription?

          1. karen jay

            My husband just told me he ordered one called Ultra-Sonic Nebulizer. Even though it is very different than the Breathe EZ atonomizer, it comes with some Asthmanephrin that doesn’t expire until March, 2016. It is supposed to work well with this medicine. If this works, I’ll let you know. It cost $54. On the tracker, t’s saying, it will get here tomorrow now. I didn’t need a prescription. Can’t wait to see if it works.
            My husband said he got it on E-Bay and there were about 35 left. If this one works, I will order the one you mentioned also because it’s so small, I will be able to take it with me. This Ultra-Sonic Nebulizer looks too big to take with. I hope you are finding something to help you! We didn’t know you could find these on the internet to work with this Asthmanephrine solution. Thanks again!

          2. Trench Reynolds

            Great, please let me know how it goes. 🙂

          3. karen jay

            Hi! I had a problem with this new Ultra-Sonic Nebulizer but I finally figured out what I did wrong when setting it up and it works great! It’s a good product but the instructions were terrible. They are written in English with a Chinese interpretation. I kept thinking, huh? every time I read the instructions. So, finally, I realized, I had to add distilled water with the medicine, in the medicine cup, up to the mid-line. I had just put in the medicine alone and it wouldn’t work since it was such a small amount, from the vial, of Racephinephrine. It is cool to see this work. It’s a great invention! Thanks for your interest and concern. Good luck with your Albuterol problems!

    2. DB

      I work in the construction industry and am sometimes exposed to Sprayfoam insulation which I am apparently allergic to. Exposure causes me to wheeze at night and I have to literally force my lungs to inhale and exhale or my body won’t do it. Asthmanefrin is the only thing that helps and mine stopped working a few months back but that’s my fault because I didn’t clean it properly. As long I took a q-tip to it after use it worked fine. I empathize with you KJ. How does that new thing work?

      1. Se

        It’s not that your allergic to’s that these are dangerous chemicals. you shouldn’t be around the stuff with out putting a mask on it’s ruining your lungs

  2. Christina Varner

    If you call the 800 number they replace the medicine cups. I have had two atomizers for about a year. I do clean them as they say and it does eventually stop working. However, I have only had the cups replaced twice. All in all it works fairly well but I do miss Primatene Mist.

    1. Trench Reynolds

      But now you can’t even find the atomizers in stores.

  3. Barbara McLean

    I just received a reply to my request for replacement nebulizer – this is what they said:

    Thank you for your email. We regret to inform you that Nephron Pharmaceuticals no longer distributes or sells the EZ Breathe Atomizer, nor any of its components. We sincerely apologize for this inconvenience. Asthmanefrin is still available for purchase for use with a rubber bulb nebulizer. Nephron does not manufacture this type of device however we would recommend you try calling your local pharmacy or search the internet to find a distributor. For your ongoing intermittent asthma needs, please consult your physician.

    Now, Nephron will honor requests for refunds with a valid proof of purchase within the warranty period of the device. Please contact our Customer Service at 1-855-999-3926 for refunding information. We are open Monday through Friday from 8 a.m. to 5 p.m. Eastern Standard Time (EST).

    It is disturbing that the refills are still being sold – they will be useless if you can’t find the nebulizer.

    1. Trench Reynolds (Post author)

      I use this nebulizer and mix the solution with distilled water and it works for me. However your results may vary.

  4. Jerry Edward

    I called the company, Nephron Pharmaceuticals (the horses mouth) and they informed me that it was ONLY the starter kit that was pulled off the market because the nebulizer was not working properly. Nephron is offering a nebulizer from MicroVaporDevices. Strangely, they (the FDA) requires a prescription from your doctor. Just have your doctor email a Rx to They are charging $79.95 for the nebulizer.
    Even my local CVS pharmacy told me that Asthmaneferin was discontinued. It is simply not true. This company originally produced Primatene Mist before the FDA got it’s crooked hands on it. I am like others, without Asthmaneferin I would have to live in a hospital where I can get a supply of epinephrine. I almost died from Albuterol and the doctors kept dosing me with more Albuterol – idiots.

    1. CA Pete

      Asthmaneferin is not discontinued, buy at Walmart, ask at pharmacy, usually kept in the back.

  5. CA Pete

    The nebulizer is ClinicalGuard HL100, you can buy the top as a part for $30. If you rinse it and place it in water with alcohol/chloroseptic right after use it lasts a long time.


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